자폐증 발달에 maternal effect가 미치는 영향은 거의 없거나 미미하다

cohot

#1

스웨덴 코호트 77만명 조사,

  • 1998 to 2007 birth cohort
  • non-twin and family data.

이 중 만명의 자폐성 범주 장애 아동들을 조사하면서 maternal effect가 자폐증 발달에 미치는 영향은 거의 없거나 미미하다(contribution ~ 0.4%)고 밝혀냄.

Additive genetic contribution은 84.8%.

Maternal effect는 다음을 포함:

  • maternal immune status
  • maternal obesity
  • polycystic ovary syndrom
  • hypertensive disorders of pregnancy
  • gestational diabetes.

Figure 1

Flow chart describing the study population. AD, autistic disorder; ASD, autism spectrum disorder; ID, identification; SD, Asperger and pervasive development disorders not otherwise specified combined.

Figure 2

gr2

Family recurrence risk ratio (FRR) with 95% confidence intervals (CIs), by outcome and type of sibling/cousin relations. AD, autistic disorder; ASD, autism spectrum disorder; SD, Asperger and pervasive development disorders not otherwise specified combined.

Figure 3

gr3

Fraction of total variation explained by each variance component with 95% confidence interval (CI), by outcome. AD, autistic disorder; ASD, autism spectrum disorder; SD, Asperger and pervasive development disorders not otherwise specified combined.

reference

출처: http://www.biologicalpsychiatryjournal.com/…/S0006…/abstract